Welcome

Welcome!

Dr. Susanta Roychoudhury

Senior Principal Scientist

Ph.D. Calcutta University, 1985

Current Research Interest

Genetic and epigenetic alterations of mismatch repair and spindle assembly checkpoint genes in oral cancer are being analysed to understand the molecular basis of genomic instability. The mechanism of spindle assembly checkpoint is being investigated to understand its role in aneuploidy.

Systematic search for the single nucleotide polymorphisms in DNA repair genes is being carried out to identify the susceptibility alleles for the development of oral cancer.

We are studying the association between cytokine and chemokine genes polymorphisms and Helicobacter pylori mediated gastroduodenal diseases. We are also performing the functional analysis of disease-associated polymorphisms to understand the biochemical basis of disease susceptibility.

Students

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Mr. Sanjib Dey

Mr. Somsubhra Nath, SRF

Mr. Pinaki Mondal, SRF

Ms. Sumana Bhattacharjya, SRF

Ms. Tania Das, SRF

Mr. Debrup Sen, JRF

Mr. Arindam Datta, PA

Mr. Kayum Alam, JRF

Ms. Sangeeta Ghuwalewala, JRF

Mr. Chetan Kumar Jain, JRF

Mr. Abhishek Chowdhury, JRF

Shaikh Md. Vaseem, PA-II

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Alumni Members

Staff

Mr. Bhaskar Basu

Technical Group I (4)

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The lab

Instruments and facilities:

Next generation sequencing facility (SOLiD, Ion torrent)

Automated DNA Sequencer (16 Capillary and 4 Capillary)

Real Time PCR (ABI 7500 Fast, Step One Plus)

Picodrop Spectrophotometer

Tissue Culture Facility

Chemidoc and Geldoc intregated system

Gallary:

pico.JP
instrumets1.JP
RT.JP
robotics.JP
gel.JP
4seq.JP
16seq.JP
DSC06423.JP
DSC06422.JP
DSC06419.JP
DSC06417.JP
DSC06416.JP
DSC06415.JP
DSC06414.JP

Publications

Important Publications:

Chakrabarti, S., Dasgupta, S., Roy, S., Bhar, A., Sengupta, A., Roy, A., Ray, K., Bhattacharyya, N. P., Roy, B., Panda, C. K. and Roychoudhury, S. Microsatellite instability in squamous cell carcinoma of head and neck from the Indian patient population, Int. J. Cancer 92: 555-561 (2001)

Basu, A., Mukherjee, N., Roy, S., Sengupta S., Banerjee S., Chakraborty M., Badal Dey, Roy M. Roy B., Bhattacharyya N. P., Roychoudhury S. and Majumder P. P. Ethnic India: A Genomic View, with Special Reference to Peopling and Structure. Genome Res. 13: 2277-2290 (2003)

The Indian Genome Variation Consortium, The Indian Genome Variation database (IGVdb): a project overview, Hum Genet 118: 1-11 (2005)

Mitra S., Sikdar N., Misra C., Gupta S., Paul R. R., Roy B., Panda C. K. and Roychoudhury S. Risk assessment of p53 genotypes and haplotypes in tobacco associated leukoplakia and oral cancer patients from eastern India. Int J Cancer 117: 786-793 (2005)

Chakravorty M., Ghosh A., Choudhury A., Santra A., Hembrum J., Roychoudhury S. Interaction between IL1B gene promoter polymorphisms in determining susceptibility to Helicobacter pylori associated duodenal ulcer. Human Mutation 27: 411-419 (2006)

Mondal G., Sengupta S., Panda C. K., Gollin S.M., Saunders W. S. and Roychoudhury S. Overexpression of Cdc20 leads to impairment of the spindle assembly checkpoint and aneuploidization in oral cancer. Carcinogenesis 28:81-92 (2007)

Sengupta S., Chakrabarti S., Roy A., Panda C. K. and Roychoudhury S. Inactivation of hMLH1 and hMSH2 in HNSCC tumors and leukoplakia by promoter hypermethylation and its relation with MIN phenotype. Cancer 109:703-712 (2007)

Chakravorty M., Datta De D., Choudhury A., and Roychoudhury S. IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin. Int. J. Biochem. Cell Biol., 41:1502-1510 (2009)

Banerjee T., Nath S. and Roychoudhury S. DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling. Nucleic Acids Res., 37:2688-2698 (2009)

Misra C., Majumder M., Bajaj S., Ghosh S., Roy B. and Roychoudhury S. Polymorphisms at p53, p73 and MDM2 loci Modulate the risk of Tobacco Associated Leukoplakia and Oral Cancer. Mol Carcinogenesis Feb. 2009; DOI: 10.1002/mc.20523

Ms. Dipanjana Datta De

Information will be uploaded

Topic of Ph.D.: Molecular genetics of Helicobacter pylori mediated gastroduodenal diseases

PhD: Submitted 2010

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Ms. Swati Bajaj

Information will be uploaded

Topic of Ph.D.: Molecular genetics of p53 mediated tumorigenesis and its potential as

a therapeutic target

Ph.D.: 2010, Jadavpur University

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SSN

Mr. Somsubhra Nath

Senior Research Fellow (CSIR)

M.Sc. Biochemistry

Topic of Ph.D.: Transcriptional regulation of mitotic ubiquitin conjugating enzyme UbcH10 and it's role in human cancer

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Mr. Sanjib Dey

Research Fellow (NMITLI project)

M.Sc. Biotechnology

Topic of Research: Discovery and Validation of New Biomarkers for Head & Neck Cancer in India

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Mr. Pinaki Mondal

Senior Research Fellow (CSIR)

M.Sc. Microbiology

Topic of Ph.D.: Susceptible allele identification of Head and Neck Squamous Cell Cancer in Indian population

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SBC

Ms. Sumana Bhattacharjya

Senior Research Fellow (UGC)

M.Sc. Genetics

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Ms. Tania Das

SRF-Lady TATA

M.Sc. Bioinformatics

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Mr. Debrup Sen

Junior Research Fellow (UGC)

M.Sc. Zoology

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RKP

Mr. Rajat Kumar Pal

Graduate Teaching Assistant Miami University, Ohio, USA

M.Sc. Microbiology

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Mr. Arindam Datta

Project Assistant (CSIR)

M.Sc. Biotechnology

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Mr. Kayum Alam

Junior Research Fellow (CSIR)

M.Sc. Biotechnology

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Mr. Chetan Kumar Jain

Junior Research Fellow (UGC)

M.Sc. Biochemistry

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Mr. Abhishek Chowdhury

Junior Research Fellow (CSIR)

M.Sc. Biochemistry

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Mr. Bhaskar Basu

Technical Group I (4)

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Alumni

Alumni Members

Soma Banerjee

Sangita Roy

Sayan Mitra

Meenakshi Maitra

Gourish Mondal

Shiladitya Sengupta

Chaitali Misra

Taraswi Banerjee

Dipanjana Dutta De

Swati Bajaj

Rajat Kumal Pal

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Meenakshi Maitra , (PhD)

Present affiliation:

Postdoctoral Fellow,

McDermott Center for Human Genetics,

UT Southwestern Medical Center, USA

Title of thesis: Studies on Genetic Susceptibility to Helicobacter pylori mediated Gastroduodenal DIseases

PhD: 2006,Jadavpur University

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Gourish Mondal, (PhD)

Present affiliation:

Research Fellow,

Stabile- 2- 43;

Dept of Lab Medicine and Pathology,

Mayo Clinic, College of Medicine

200 1st Street SW, Rochester

MN, 55905, USA

Title of thesis: Understanding the Molecular Mechanism of Genomic instability in Head and Neck Squamous Cell Carcinoma: Role of Spindle Assembly Checkpoint Genes.

Ph.D.: 2007, Jadavpur University

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SSG

Shiladitya Sengupta, (PhD)

Present affiliation:

Visiting Scientist,

Department of Biochemistry and Molecular Biology,

University of Texas Medical Branch,

Galveston, USA

Title of thesis: Altered DNA Repair Pathways and Genome Instability: Possible Connection in the Development of Head and Neck Squamous Cell Carcinoma.

PhD: 2008, Jadavpur University

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SGW

Ms. Sangeeta Ghuwalewala

CSIR-JRF

M.Sc. Biotechnology

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Chaitali Misra, (PhD)

Present affiliation:

Postdoctoral fellow

Garg Lab

Nationwide Children's Hospital

Center for Cardiovascular & Pulmonology Research

Ohio State University

Columbus, OH

Title of thesis: Analysis of polymorphic variants of wild type and mutant p53 gene in head and neck cancer.

Ph.D.: 2009, Jadavpur University

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Taraswi Banerjee, (PhD)

Present affiliation:

Post-doctoral fellow,

Department of Obstrectis and Gynaecology, Northwestern University, Chicago, Illinois, USA

Title of thesis: Study of the regulation of Spindle Assembly checkpoint gene CDC20

and its role in genomic instability in human cancer

PhD: 2010, Jadavpur University

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Sayan Mitra, (PhD)

Present affiliation:

Sr. Scientist. GVKBIO pvt ltd,

Hyderabad, India

Title of thesis: Molecular Analysis of p53 gene alterations in oral leukoplakia and

Head and Neck Cancer

PhD: 2006, Jadavpur University

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Sangita Roy, (PhD)

Present affiliation:

Associate Prof, HOD Biochemistry, Oxford College of Science, Bangalore, India

Title of thesis: Genomic Structure of Ethnic Populations Of India As Revealed By

Mitochondrial DNA Polymorphisms

PhD: 2002, Jadavpur University

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SOB

Soma Banerjee, (PhD)

Present affiliation:

Associate Professor

Centre for Liver Research,

School of Digestive & Liver Diseases

Institute of Post Graduate -

Medical Education and Research

1st Floor, 244 A.J.C Bose Road.

Kolkata-700020.India

Title of thesis: High resolution physical map of Vibrio cholerae 569B genome

PhD: 1999, Jadavpur University

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Shaikh Md. Vaseem

M. Pharm (NIPER-Kolkata)

Project Assistant Level-II

Topic of Research: Information will be uploaded.

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SRC

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