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Young-Pil Kim Ph.D.Molecular Imaging Program at StanfordDept. of RadiologyStanford School of MedicineLucas Expansion, P0891201 Welch RoadStanford, CA 94305-5484Phone: (650) 724-2644Fax: (650) 736-7925E-mail: ypkim_stanford.edu Toward a New Philosophy of BiologyLife at a Glance: Between BIO and NANO"I can be aware of life from inorganic nanoparicles. They are dynamic, breathing, even moving to where they want to go. They are not non-living things any more" "Molecules in a living cell are like stars in the Universe. Nanoworld is always open to cosmos in our sights" "Living is like loving. Loving someone means that I'm still alive, and loving one another means that we're still alive." "The role that biological processes in the life of an organism cannot be described by reference only to physical laws or chemical reactions." — Ernst MayrSpecial offer

Educational Backgroud

• Ph.D. Dept. of Biological Sciences, KAIST (Mar 2004-Feb 2008)

(Thesis Title: Development of Nanoparticle-Based Biochip System for Detection of Post-Translational Modifications of Protein)

• M.Sc. Dept. of Life Science, Hanyang University, Seoul (Aug 1998-Aug 2000)

(Thesis Title: Resting Cell, Ploidy Pattern and Intraspecific Genetic Variation in Cultured Heterosigma akashiwo (Raphidophyceae))

• B.Sc. Dept. of Biology, Hanyang University, Seoul (Mar 1992-Feb 1996)

Experiences• Postdoctoal Scholar in Dept. of Radiology, School of Medicine, Stanford (Dec 2008~ present)

• Postdoctoal Scholar in Dept. of Biological Sciences, KAIST (Feb 2008~Dec 2008)

• Research Manager in KoreaBiosystems Co. Ltd. (2001~2003)

• Team Leader in KoreaBiosystems Co. Ltd. (2000~2001) (founded in KIST)

• Visiting Student in Dept. of Biological Sciences, Univ. of Washington, Seattle, WA, USA (1998-1999)

• Korean Army Service (ROTC #34) (1996-1998)

Honors and Awards• BK-21 Prize for an excellent scientist at KAIST (Jan. 2008)

• The 6th Bioneer Best Award for the Annual Patent at KAIST (Mar. 2007.)

• Bronze Prize in the 2nd Bio-Essay Contest (2006) hosted by KRIBB and MOST

• Graduate Student Fellowship at KAIST (2004~2008)

• University Fellowship at Univ. of Washington (funded by NOAA Washington Sea Grant, 1998~1999)

• University Graduate Student Fellowship at Hanyang Univ. (1998~2000)

• Student representative of ROTC Unit at Hanyang Univ. (1996)

• Undergraduate Student Fellowship at Hanyang Univ. (funded by Samyang Corporation, 1993~1994)

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Scientific Publications

25. Young-Pil Kim, Weston L. Daniel, Zuyong Xia, Hexin Xie, Chad A. Mirkin, and Jianghong Rao. Bioluminescent Nanosensors for Protease

Detection Based upon Gold Nanoparticle-Luciferase Conjugates.2009. Chem. Comm. In Press

24. Hongjun Ren, Fei Xiao, Ke Zhan, Young-Pil Kim, Zuyong Xia, and Jianghong Rao. Biocompatible Condensation Reaction for Labeling of N-

Terminal Cysteine on Proteins. 2009. Angew. Chem. Int. Ed. In Press

23. Zongwen Jin, Young Ki Hahn, Eunkeu Oh, Young-Pil Kim, Je-Kyun Park, Seung Ho Moon, Jung-Tak Jang, Jinwoo Cheon, and Hak-Sung Kim.

Magnetophoretic Nanoclusters for Ultrasensitive Magnetophoretic Assay.2009, Small Published online

22. Young-Pil Kim, Zongwen Jin, Sunyoung Park, Young-Hee Oh, Eunkyung Kim and Hak-Sung Kim. Analysis of in vitro SUMOylation using

bioluminescence resonance energy transfer (BRET). 2009. Biochem. Biophys. Res. Commun. 382, 530-534.

21. Ji-Won Park, Hyegeun Min, Young-Pil Kim, Hyun Kyong Shon, Jinmo Kim, Dae Won Moon, and Tae Geol Lee. Multivariate Analysis of

ToF-SIMs Data for Biological Applications. 2009. Surface and Interface Analysis, 41(8), 694-703

20. Young-Pil Kim, Sunyoung Park, Eunkeu Oh, Young-Hee Oh, and Hak-Sung Kim. On-Chip Detection of Protein Glycosylation Based on

Energy Transfer between Nanoparticles. 2009. Biosens. Bioelectron. 24, 1189-1194.

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19. Young-Pil Kim, Bong Soo Lee, Eunkyung Kim, Insung S. Choi, Dae Won Moon, Tae Geol Lee, and Hak-Sung Kim. Activity-Based Assay

of Matrix Metalloproteinase on Nonbiofouling Surfaces Using Time-of-Flight Secondary-Ion Mass Spectrometry. 2008. Anal. Chem. 80(13),

5094-5102

18.Young-Pil Kim, Young-Hee Oh, Eunkyu Oh, Sungho Ko, Min-Kyu Han, and Hak-Sung Kim. Energy Transfer-Based Multiplexed Assay of

Proteases by Using Gold Nanoparticle and Quantum Dot Conjugates on a Surface. 2008. Anal. Chem. 80(12), 4634-4641.

17. Eunkyung Kim, Bong Soo Lee, Hyeon-Bong Pyo, Hyun-Woo Song, Young-Pil Kim, Insung S. Choi and Hak-Sung Kim. Fabrication of

Nonbiofouling Surface and I.ts Application to Surface Plasmon Field-Enhanced Fluorescence Spectroscopy. 2008. Biochip J. 2(2), 103-

110.

16. Young-Pil Kim, Mi-Young Hong, Won Chegal, Hyunmo Cho, Dae Won Moon, Hak-Sung Kim, and Tae Geol Lee. Protein Quantification on

Dendrimer-Activated Surfaces by Using Time-of-Flight Secondary Ion Mass Spectrometry. 2008. Appl. Surf. Sci. 255, 1110-1112.

15. Young-Pil Kim, Eunkeu Oh, Dae Won Moon, Tae Geol Lee and Hak-Sung Kim. Gold Nanoparticle-Enhanced Secondary Ion Mass

Spectrometry and Its Bio-Applications. 2008. Appl. Surf. Sci. 255, 1064-1067.

14. Young-Pil Kim, Young-Hee Oh, and Hak-Sung Kim. Protein Kinase Assay on Peptide-Conjugated Gold Nanoparticles. 2008. Biosens.

Bioelectron. 23(7), 980-986.

13. Jang-Hyuk Ahn, Young-Pil Kim, Yu-Mi Lee, Eun-Mi Seo, Ki-Woong Lee and Hak-Sung Kim. Optimization of Microencapsulation of Seed

Oil by Response Surface Methodology. 2008. Food Chem. 107(1), 98-105.

12. Jang-Hyuk Ahn, Young-Pil Kim, Eun-Mi Seo, Young-Ki Choi, and Hak-Sung Kim. Antioxidant Effect of Natural Plant Extracts on the

Microencapsulated High Oleic Sunflower Oil. 2008. J. Food Eng. 84(2), 327-334

11. Young-Pil Kim, Young-Hee Oh, Eunkyu Oh, and Hak-Sung Kim. Chip-Based Protease Assay Using Fluorescence Resonance Energy

Transfer between Quantum Dots and Fluorophores. 2007. Biochip J. 1(4), 228-233.

10. Young-Pil Kim, Kun Cho, Dohoon Lee, Yunxian Piao, Yeong Hee Ahn, Jong Shin Yoo, Taeghwan Hyun and Hak-Sung Kim. Efficient

Enrichment and Desalting of Protein Digests Using Magnetic Mesocellular Carbon Foams in Matrix-Assisted Laser Desorption/Ionization

Mass Spectrometry. 2007. Rapid Commun. Mass Spectrom. 21(21), 3435-3442.

9. Young-Pil Kim, Eunkeu Oh, Young-Hee Oh, Dae Won Moon, Tae Geol Lee, and Hak-Sung Kim. Protein Kinase Assay on Peptide-

Conjugated Gold Nanoparticles by Using Secondary-Ion Mass Spectrometric Imaging. 2007. Angew. Chem. Int. Ed. 46(36), 68166819.

8. Dong-Yoon Jang, Young-Pil Kim, Hak-Sung Kim, Sang-Hee Ko Park, Sung-Yool Choi and Yang-Kyu Choi. Sub-lithographic Vertical Gold

Nanogap for Label Free Electrical Detection of Protein-Ligand Binding. 2007. J. Vac. Sci. Technol. B. 25(2), 443447.

7. Young-Hee Oh, Young-Pil Kim, and Hak-Sung Kim. SUMO(Small Ubiquitin-like Modifier) Chip for Analysis of SUMO-conjugation to a

Target Protein. 2007. Biochip J. 1(1) 28-34.

6. Young-Pil Kim, Mi-Young Hong, Jinmo Kim, Eunkeu Oh, Hyun Kyong Shon, Dae Won Moon, Hak-Sung Kim, and Tae Geol Lee.

Quantitative Analysis of Surface-Immobilized Protein by TOF-SIMS: Effects of Protein Orientation and Trehalose Additive. 2007. Anal.

Chem. 79(4) 1377-1385.

5. Eunkeu Oh, Dohoon Lee, Young-Pil Kim, Seung Youp Cha, Doo-Beyong Oh, Hyun Ah Kang, Jungbae Kim, and Hak-Sung Kim.

Nanoparticle-based Energy Transfer for a Rapid and Simple Detection of Protein Glycosylation. 2006. Angew. Chem. Int. Ed. 45(47),

7959-7963.

4. Young-Pil Kim, Mi-Young Hong, Hyun Kyong Shon, Dae Won Moon, Hak-Sung Kim, Tae Geol Lee. Quantitative TOF-SIMS Study of

Surface-Immobilized Streptavidin. 2006. Appl. Surf. Sci. 252, 6801-6804.

3. Young-Pil Kim, Eunkeu Oh, Mi-Young Hong, Dohoon Lee, Min-Kyu Han, Hyun Kyong Shon, Dae Won Moon, Hak-Sung Kim, and Tae

Geol Lee. Gold nanoparticle-enhanced secondary ion mass spectrometry imaging of peptides on self-assembled monolayers. 2006. Anal.

Chem. 78(6), 1913-1920.

2. Jinwoo Lee, Dohoon Lee, Eunkeu Oh, Jaeyun Kim, Young-Pil Kim, Sunmi Jin, Hak-Sung Kim, Yosun Hwang, Ja Hun Kwak, Je-Geun

Park, Chae-Ho Shin, Jungbae Kim, and Taeghwan Hyeon. Preparation of a magnetically switchable bioelectrocatalytic system employing

cross-linked enzyme aggregates in magnetic mesocellular carbon foam. 2005. Angew. Chem. Int. Ed. 44(45), 7427-7432.

1. Myung-Soo Han,* Young-Pil Kim,* and Rose Ann Cattolico* (*equally contributed) Heterosigma Akashiwo (Raphidophyceae) resting cell

formation in batch culture: Strain identity versus physiological response. 2002. J. Phycol. 38(2), 304-317.

Patents

9. Novel construction of gold nanoparticle-based peptide chip, and assaying enzyme activity and inhibitor effect using secondary ion mass

spectrometric analysis thereof. USA Patent Application No. 11/711,036 (Feb 27, 2007) Public No. US2008/0076676 A1 (Mar 27, 2008)

8. Method for assaying mycotoxin. KR Patent Application No. 10-2008-0020343 (Mar. 5. 2008).

7. Nanoaprticle-based biochip set for detecting glycoproteins. KR Patent Application No. 10-2008-0018342 (Feb 29. 2008).

6. A method of nanogap electrode device. KR Patent Application No. 10-2007-0116410 (Nov. 15, 2007).

5. Quantum dot-based biochip and method for assaying hydrolytic proteins using the same. KR Patent No. 10-0883547 (Feb. 6, 2009) .

4. Detection method for the reaction between biomolecules and protein using biochip based on the monolayer of gold nanoparticles. KR

Patent No. 10-0869909 (Nov. 17, 2008).

3. Method for enrichment and desalting of peptides using magnetic mesoporous carbon foams, and application thereof to mass

spectrometric analysis. KR Patent No. 10-0784479 (Dec. 4, 2007).

2. Novel construction of gold nanoparticle-based peptide chip, and assaying enzyme activity and inhibitor effect using secondary ion mass

spectrometric analysis thereof. KR Patent No. 10-070723 (Jul. 12, 2007)

1. Composite electrode for electrochemical COD measurement. ;KR Patent No. 10-0623933 (Sep. 7, 2006); WIPO(P.C.T.) Patent No.

WO04/025672 (3/25, 2004) ; AU(Australia) Patent No. 2003261001 (4/30, 2004)

Book Chapter

3. Young-Pil Kim. Science and Reality in the viewpoint of biologist. pp 327-341. The 1st and 2nd Korea Bioessay Winners (2005-2006).

2006. Osong Bio Promotion Foundation

2. Dohoon Lee, Jinwoo Lee, Young-Pil Kim, Jungbae Kim, Taeghwan Hyeon and Hak-Sung Kim, Highly Sensitive and Magnetically

Switchable Biosensors Using Ordered Mesoporous Carbons. pp234-242, in Biomolecular Catalysis : Nanoscale Science and Technology

Eds. Kim, Jungbae; Kim, Seong H.; Wang, Ping; American Chemical Society, 2008, OXFORD UNIVERSITY PRESS

1.Myung-Soo Han, Young-Ok Kim, Myung-Hwan Park, Uksae Lee, Young-Pil Kim, Sooyeon Cho. Germination and blooming of cysts in

harmful marine algae. Dedication to Professor Jae Hyung Shim. pp 139-156 in Biological Oceanography in Korean (The Plankton Ecology

of Korean Coastal waters). 2003, Donghwa

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